Scanning electron microscopy (SEM) has become an integral technology in biotechnology, life sciences and medical science research. Recent investigations of cell morphology, development of biocompatible materials, tissue engineering research, microbiology and many more heavily rely on advanced SEM imaging techniques. TESCAN develops and manufactures state-of-the-art electron microscopy solutions customised to every life science application. The broad range of dedicated instrumentation helps scientists and researchers in all fields to make stunning discoveries and move science forward.
The surface properties and interactions between the material and tissue are keys for predicting the biocompatibility of the material with the host body. This is particularly important in designing reliable implants, tissue mimics and bone replacements, among others. TESCAN SEM systems are ideal instruments for the characterization of biomaterials with high resolution. Wide Field Optics™ allows easy navigation on the sample at very low magnification in real time.
- Once the region of interest is found, the SEM column can be easily switched to high depth of field or high resolution modes for detail inspection of the features at high magnification.
- All instruments can be easily equipped with a wide variety of detectors and analytical methods such as EDX and EBSD analysers, Raman spectrometers for detailed compositional and structural analyses of biomaterials.
- Non-coated and highly charging samples can be observed either by using low accelerating voltages or under variable pressure conditions in the UniVac mode. With our dedicated FIB-SEM systems, researchers can cut directly into the materials and investigate material-tissue interfaces or reconstruct them in 3D.
In addition to its structural role, the membrane is also a place, where many important events occur, such as cell differentiation, signalling and interactions with extracellular space. Changes in the morphology of the outer membrane can be an evidence of altered cellular functions, such as tumour formation, cell-pathogen interactions and stem cell differentiation. Typical applications involve observing shape changes of grooves, pores, blebs or microvilli on the cellular in response to the changes in the extracellular environment. Delicate samples can be observed in non-dehydrating conditions in under elevated pressure and increased humidity using the UniVac mode and the Water Vapor Inlet.
- TESCAN MIRA3 and MAIA3 FEG-SEMs are ideal instruments for investigating cellular and tissue structure with high resolution.
- The MAIA3 is specifically designed for ultra-high resolution imaging at low accelerating voltages, thus providing the best topographic contrast and detail.